Although the proliferation capacity is inferior to UCMSCs.Īdipose Menstrual blood Mesenchymal stem cell Umbilical cord.Ĭopyright © 2015 Hainan Medical College. Sox9 is a transcription factor that regulates chondrogenesis, but its role in the chondrogenic differentiation of mesenchymal stem cells (MSCs) triggered by materials is poorly understood. MenSCs have higher extraction efficiency, colony-forming ability, and long time passage capacity. In addition, MenSCs appeared to be superior in terms of immune inflammation, stress response, and neural differentiation potentials, but weaker in terms of osteogenic and chondrogenic differentiation capacities, compared with UCMSCs and bone marrow-derived MSCs. Based on gene-expression data for MSCs from different sources within the same donor, 768 MenSC genes were found that were specifically upregulated or downregulated compared with bone marrow-derived MSCs and UCMSCs, most of which were involved in cell function-related pathways. The proliferation rate decreased in the order UCMSCs > MenSCs > ADSCs, while the colony-forming ability decreased in the order MenSCs > ADSCs > UCMSCs. Until recently, researchers thought adult stem cells could create only similar types of cells. Compared with embryonic stem cells, adult stem cells have a more limited ability to give rise to various cells of the body. Large-scale expansion of highly functional adult human mesenchymal stem cells (aMSCs) remains technologically challenging as aMSCs lose self renewal capacity and multipotency during traditional long-term culture and their quality/quantity declines with donor age and disease. Umbilical cord-derived MSCs (UCMSCs) were able to overcome density inhibition. These stem cells are found in small numbers in most adult tissues, such as bone marrow or fat. The stem cells (SCs) obtained from different sources were all characterized as MSCs, but demonstrated some differences. The term somatic refers to non-reproductive cells in the body (eggs or sperm). In this study, MSCs were isolated from adipose tissue (AD), umbilical cord tissue (UC), and menstrual blood (Men) and compared their biological characteristics in terms of proliferation capacity, passage capacity, colony formation, and surface markers were compared. You may also see the term somatic stem cell used to refer to adult stem cells. To invest the differences among mesenchymal stem cells (MSCs) derived from different tissues and their impacts on clinical applications.
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